I have installed my Plugwise software on the Homeseer machine.
USB connection was there but did not work..because of some driver problem (FTDI)
After upgrading the FTDI driver Plugwise is working fine.
There is also another nice option in the Belkin control software.
You can launch the correct application after the correct USB dongle is connected.
In my case the PlugwisePC.exe will be started
This option can also be used for auto starting the Homeseer if the PMIX35 or the CMXX is connected.